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LGD 4033 binds itself exclusively to skeletal muscle and bone tissue and does not cause harm to the prostate or other vital organs(5).A variety of other factors, such as diet, exercise, and certain medications, may influence the development of GH resistance, and studies have shown that different levels of GH in different people produce different and sometimes opposing effects. The specific GH resistance that occurs in men is determined by the degree of GH resistance to insulin.Diabetes mellitus affects the production of GH when it exceeds normal levels. This affects men with GH resistance to insulin. The rate of glucose absorption increases, the rate of action of pancreatic beta-cell hormone increases, and the level of beta-cell hormone (proinsulin) begins to rise. In response to the rising levels, glucose and insulin are absorbed into the bloodstream, leading to increased blood sugar levels and decreased fatness.Some cases of GH resistance appear to be related to a failure of beta-cell function to produce the proper amount of insulin required to raise GH levels. It has been shown that elevated blood glucose and high insulin levels impair normal beta-cell function (21,22). This may be especially true in type II or III beta-cells, that do not make insulin properly (23). A high-fat diet is a risk factor for GH resistance in type II or III beta-cells. These cells are more susceptible to insulin and less so to glucose. However, high-fat diets do not result in increased plasma leptin levels, which are the principal androgen receptor marker of GH resistance (24).When we raise GH to the level that is required to maintain a normal rate of fat burning, the body produces free fatty acids into the blood. There is still the potential for fat storage. However, for the majority of men, fat is actually eliminated in the urine.In addition to raising and lowering GH, insulin levels also produce some effects on the functioning of the prostate gland that may contribute to GH deficiency as well. This is often not noticeable, because of the long hours spent sleeping. Insulin resistance can lead to impaired secretion of prostate-specific antigen (PSA), which is a marker of prostate function and sensitivity.For example, it can contribute to symptoms of low libido, or it may lead to premature ejaculation, or delayed ejaculation and decreased ejaculatory frequency.It may be interesting to note that when diabetes mellitus appears to be associated with GH deficiency, this may be because of insulin resistance or a deficiency of glucagon, a hormone that is required to stimulate the release of free fatty acids from the liverRelated Article: